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Hematopoietic stem cell gene therapy to halt neurodegeneration

1 Jul 2024

Abstract excerpt

Microglia play fundamental roles in multiple pathological primary and secondary processes affecting the central nervous system that ultimately result in neurodegeneration and for this reason they are considered as a key therapeutic target in several neurodegenerative diseases. Microglia-targeted therapies are directed at either restoring or modulating microglia function, to redirect their functional features...

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PMID: 39276677
DOI: 10.1016/j.neurot.2024.e00440

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