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Article

Stem cell derived human microglia transplanted in mouse brain to study genetic risk of Alzheimer’s Disease

2019-02-27

Abstract excerpt

<h4>Summary paragraph</h4> Genetics highlight the central role of microglia in Alzheimer’s disease but at least 36% of AD-risk genes lack good mouse orthologues. Here, we show that embryonic stem cell (ESC)-derived human microglia successfully engraft the mouse brain and recapitulate transcriptionally primary human microglia derived from human surgical samples. Upon exposure to oligomeric Aβ a wide range of AD-ri...

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Literature Corpus work
60f4e772-97dd-5c56-9715-daa6548631c5
DOI
10.1101/562561
Open publication

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