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A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer’s Disease

2024-03-14

Abstract excerpt

<h4>SUMMARY</h4> While challenging, identifying individuals displaying resilience to Alzheimer’s disease (AD) and understanding the underlying mechanism holds great promise for the development of new therapeutic interventions to effectively treat AD. Down syndrome (DS), or trisomy 21, is the most common genetic cause of AD. Interestingly, some people with DS, despite developing AD neuropathology, show resilience...

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Literature Corpus work
2b1bfb09-f234-540b-81dd-8d36e2e26484
DOI
10.1101/2024.03.12.584646
Open publication

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A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer’s DiseaseDOI 10.1101/2024.03.12.584646
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