Article

HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model

2023-04-27

Abstract excerpt

The central nervous system (CNS) is a major human immunodeficiency virus type 1 reservoir. Microglia are the primary target cell of HIV-1 infection in the CNS. Current models have not allowed the precise molecular pathways of acute and chronic CNS microglial infection to be tested with in vivo genetic methods. Here, we describe a novel humanized mouse model utilizing human-induced pluripotent stem cell-derived mic...

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Literature Corpus work: 9f4f4139-7c87-5b60-bdbb-2ae6bfaaa878
DOI: 10.1101/2023.04.26.538461

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