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Article

Rescue of Alzheimer's disease phenotype in a mouse model by transplantation of wild-type hematopoietic stem and progenitor cells.

Cell reports - 29 Aug 2023

Mishra Priyanka, Silva Alexander, Sharma Jay, Nguyen Jacqueline, Pizzo Donald P, Hinz Denise, Sahoo Debashis, Cherqui Stephanie

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent cause of dementia; microglia have been implicated in AD pathogenesis, but their role is still matter of debate. Our study showed that single systemic wild-type (WT) hematopoietic stem and progenitor cell (HSPC) transplantation rescued the AD phenotype in 5xFAD mice and that transplantation may prevent microglia activation. Indeed, complete prevention of memory loss...

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Identifiers

PMID: 37561625
DOI: 10.1016/j.celrep.2023.112956
PMCID: PMC10617121

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