Article

Aberrant 3′UTR splicing drives FUS-dependent mRNA condensates and prevents β-catenin from adherens junctions to promote cancer aggressiveness

2026-07-03

Abstract excerpt

The protein-coding sequence has long been considered the primary determinant of protein function. Alternative splicing within 3′UTRs (AS-3′UTRs) generates multiple transcript isoforms from a single gene, yet their roles in protein function and disease relevance remain largely unexplored. Through systematic transcriptome-wide identification of cancer-associated AS-3′UTRs, we uncover that AS-3′UTRs of β-catenin mRNA...

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Literature Corpus work: fd3fb17c-313e-5ca0-ace6-b151a703265e
DOI: 10.64898/2026.07.01.735936

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