Article
Aberrant regulation of messenger RNA 3'-untranslated region in human cancer.
Cellular oncology : the official journal of the International Society for Cellular Oncology - 1 Jan 2007
López de Silanes Isabel, Quesada María Paz, Esteller Manel
Abstract excerpt
The messenger RNA 3'-untranslated region (3'UTR) is emerging as critically important in regulating gene expression at posttranscriptional levels. The 3'UTR governs gene expression via orchestrated interactions between mRNA structural components (cis-elements) and specific trans-acting factors (RNA-binding proteins and non-coding RNAs). Alterations in any of these components can lead to disease. Here, we review...
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