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Article

3' untranslated region somatic variants connect alternative polyadenylation dysregulation in human cancers.

Journal of genetics and genomics = Yi chuan xue bao - 1 Nov 2025

Xu Qiushi, Cheng Xiaomeng, Li Qianru, Yu Peng, Zhou Xiaolan, Chen Yu, Lin Limin, Ni Ting, Zhao Zhaozhao

Abstract excerpt

Somatic variants in the cancer genome influence gene expression through diverse mechanisms depending on their specific locations. However, a systematic evaluation of the effects of somatic variants located in 3' untranslated regions (3' UTRs) on alternative polyadenylation (APA) of mRNA remains lacking. In this study, we analyze 10,199 tumor samples across 32 cancer types and identify 1333 somatic single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40107412
DOI: 10.1016/j.jgg.2025.03.006

Genes

CHTOP
HMGN2
HSPA4
RPS23
UCK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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