Back to search

Article

FET fusion proteins reshape splicing factor networks to drive oncogenic alternative splicing

2026-08-28

Abstract excerpt

Gene fusions involving the FET gene family ( FUS , EWSR1 , and TAF15 ) act as drivers of numerous cancer subtypes. The resulting chimeric proteins are widely viewed as aberrant transcriptional regulators that promote malignant transformation through chromatin and enhancer reprogramming. Here, we show that FET fusion oncoproteins also function as regulators of alternative splicing across multiple sarcoma subtype...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0ddbb276-d44c-5459-b225-076ff4299ca2
DOI
10.64898/2026.08.28.746988
Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
FET fusion proteins reshape splicing factor networks to drive oncogenic alternative splicingDOI 10.64898/2026.08.28.746988
FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complexSemantic proximity
EWS/FLI1 Characterization, Activation, Repression, Target Genes and Therapeutic Opportunities in Ewing SarcomaSemantic proximity
Identification of a novel FUS/ETV4 fusion and comparative analysis with other Ewing sarcoma fusion proteinsSemantic proximity
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis.Semantic proximity
Seclidemstat blocks the transcriptional function of multiple FET-fusion oncoproteinsSemantic proximity
Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulationSemantic proximity
The importance of fusion protein activity in Ewing sarcoma and the cell intrinsic and extrinsic factors that regulate it: A reviewSemantic proximity
Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcomaSemantic proximity
FUS and TAF15 safeguard the critical functions of the ribonucleoprotein network formed by EWSR1 and newly synthesized RNASemantic proximity
The landscape of long noncoding RNA-involved and tumor-specific fusions across various cancersSemantic proximity
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing.Semantic proximity
annoFuse: an R Package to annotate, prioritize, and interactively explore putative oncogenic RNA fusionsSemantic proximity
Select a neighboring publication to make it the new centre.