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Article

Alternative tandem transcription initiation links noncoding variants to human disease through translational control.

Nature communications - 20 Aug 2026

Zou Xudong, Wang Wei, Wang Yinuo, Chen Hui, Li Xing, Chen Shuxin, Weng Feihong, Li Yangcan, Li Qin, Yu Chen, Li Lei

Abstract excerpt

Alternative tandem transcription initiation is a pervasive mechanism of gene regulation, yet its genetic impact on human disease remains largely unknown. Here, we systematically quantify the genetic regulation of alternative tandem transcription initiation across 25,859 samples from 49 normal human tissues and 33 tumor tissues. We identify approximately 0.4 million genetic variants associated with alternative...

Read the complete abstract on PubMed

Topics

Humans
5' Untranslated Regions
Genetic Predisposition to Disease
Breast Neoplasms
Quantitative Trait Loci
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Protein Biosynthesis

Transcription Initiation, Genetic

Gene Expression Regulation, Neoplastic

Genome-Wide Association Study

Cell Line, Tumor

Genetic Variation

Polymorphism, Single Nucleotide

Gene Expression Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 42754569
DOI: 10.1038/s41467-026-76741-8
PMCID: PMC13586314

Genes

MAFF
MLLT10
OSGEP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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