Article

The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis

2020-12-06

Abstract excerpt

<h4>ABSTRACT</h4> Genomic amplification of the distal portion of chromosome 3q, which encodes a number of oncogenic proteins, is one of the most frequent chromosomal abnormalities in malignancy. Here we functionally characterise a non-protein product of the 3q region, the long noncoding RNA (lncRNA) PLANE, which is upregulated in diverse cancer types through copy number gain as well as E2F1-mediated transcription...

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Literature Corpus work: 8ceb4d47-3828-5d67-87f1-a511416696db
DOI: 10.1101/2020.12.04.412536

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