Article

Intermolecular 3′UTR-3′UTR interactions drive Wnt gene activation through heteromeric protein assembly

2026-05-07

Abstract excerpt

Stem cell differentiation depends on transcription factors that are often encoded by mRNAs with highly conserved 3′UTRs. To determine their functional roles, we performed 3′UTR loss-of-function studies. Partial deletion of endogenous 3′UTRs altered stem cell differentiation efficiency in 7/10 cases. As 6/7 3′UTR deletions did not affect expression level of the encoded proteins, we reveal widespread abundance-indep...

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Literature Corpus work: e96eda44-507b-543b-814d-22ccee94380d
DOI: 10.64898/2026.05.05.723075

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