Article

CD73 restrains mutant β-catenin oncogenic activity in endometrial carcinomas

2024-11-18

Abstract excerpt

Missense mutations in exon 3 of CTNNB1 , the gene encoding β-catenin, are associated with poor outcomes in endometrial carcinomas (EC). Clinically, CTNNB1 mutation status has been difficult to use as a predictive biomarker as β-catenin oncogenic activity is modified by other factors, and these determinants are unknown. Here we reveal that CD73 restrains the oncogenic activity of exon 3 β-catenin mutants, and its...

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Literature Corpus work: 5b43a9cc-3905-5505-abed-41598b4ce197
DOI: 10.1101/2024.11.18.624183

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