Article

Targeting CPSF73, the mRNA 3’ End Processing Endonuclease, Moves Cancer Cells Away from the Mesenchymal State

2026-03-03

Abstract excerpt

<h4>Background</h4> Metastasis significantly contributes to cancer-related mortality and therapeutic failure. Cancer cells acquire metastatic potential by losing epithelial characteristics and gaining mesenchymal properties through the epithelial-mesenchymal transition (EMT). Differential poly(A) site (PAS) usage, known as alternative polyadenylation (APA), generates mRNA isoforms differing in coding sequence, su...

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Literature Corpus work: 54a562c9-6e30-5b70-854b-b40d9b2b2c30
DOI: 10.64898/2026.03.01.708894

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