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Article

fus/TLS orchestrates splicing of developmental regulators during gastrulation.

Genes & development - 15 Jun 2012

Dichmann Darwin S, Harland Richard M

Abstract excerpt

Here we investigated the function of the atypical RNA-binding protein fus/TLS (fused in sarcoma/translocated in sarcoma) during early frog development. We found that fus is necessary for proper mRNA splicing of a set of developmental regulatory genes during early frog development and gastrulation. Upon fus knockdown, embryos fail to gastrulate and show mesodermal differentiation defects that we connect to intron...

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Identifiers

PMID: 22713872
DOI: 10.1101/gad.187278.112
PMCID: PMC3387662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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