Article

Human XIST RNA acts early to condense architecture which facilitates A-repeat density-dependent initiation of gene silencing

2022-02-05

Abstract excerpt

<h4>SUMMARY</h4> XIST RNA triggers gene silencing chromosome-wide and transforms a euchromatic chromosome into a condensed Barr body. XIST is heavily studied in mouse ES cells, but here an inducible iPSC system allows analysis of initial steps in human chromosome silencing, revealing key points not known in either system. XIST RNA distribution was examined relative to biochemical and transcriptional changes dire...

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Literature Corpus work: faad376f-d048-57b4-8852-b049fedfea1f
DOI: 10.1101/2022.02.04.479153

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