Article
Single-cell landscape of nuclear configuration and gene expression during stem cell differentiation and X inactivation.
Genome biology - 27 Sept 2021
Bonora Giancarlo, Ramani Vijay, Singh Ritambhara, Fang He, Jackson Dana L, Srivatsan Sanjay, Qiu Ruolan, Lee Choli, Trapnell Cole, Shendure Jay, Duan Zhijun, Deng Xinxian, Noble William S, Disteche Christine M
Abstract excerpt
BACKGROUND: Mammalian development is associated with extensive changes in gene expression, chromatin accessibility, and nuclear structure. Here, we follow such changes associated with mouse embryonic stem cell differentiation and X inactivation by integrating, for the first time, allele-specific data from these three modalities obtained by high-throughput single-cell RNA-seq, ATAC-seq, and Hi-C. RESULTS:...
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