Article

Dynamic Erasure of Random X-Chromosome Inactivation during iPSC Reprogramming

2019-02-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Induction and reversal of chromatin silencing is critical for successful development, tissue homeostasis and the derivation of induced pluripotent stem cells (iPSCs). X-chromosome inactivation (XCI) and reactivation (XCR) in female cells represent chromosome-wide transitions between active and inactive chromatin states. While XCI has long been studied and provided important...

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Literature Corpus work: 3ac6a8d4-27a8-54f9-b033-7df2becfc84e
DOI: 10.1101/545558

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