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Article

High-resolution analysis of epigenetic changes associated with X inactivation.

Genome research - 1 Aug 2009

Marks Hendrik, Chow Jennifer C, Denissov Sergei, Françoijs Kees-Jan, Brockdorff Neil, Heard Edith, Stunnenberg Hendrik G

Abstract excerpt

Differentiation of female murine ES cells triggers silencing of one X chromosome through X-chromosome inactivation (XCI). Immunofluorescence studies showed that soon after Xist RNA coating the inactive X (Xi) undergoes many heterochromatic changes, including the acquisition of H3K27me3. However, the mechanisms that lead to the establishment of heterochromatin remain unclear. We first analyze chromatin changes by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19581487
DOI: 10.1101/gr.092643.109
PMCID: PMC2720191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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