Article

Multiple distinct domains of human XIST are required to coordinate gene silencing and subsequent heterochromatin formation

2021-11-01

Abstract excerpt

<title>Abstract</title> <p>Background Mammalian dosage compensation is achieved by the inactivation of one X chromosome in XX individuals. In eutheria this process is initiated early in development by the long non-coding RNA XIST. Studies of the initiation of silencing by XIST have focussed on mouse models, so the domains of XIST required to induce silencing in humans, and their relationship with domains require...

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Literature Corpus work: 5ffdcc3b-ea0d-5070-b61b-f60b835becdd
DOI: 10.21203/rs.3.rs-996346/v1

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