Article

Dynamic reorganization of nuclear architecture during human cardiogenesis

2017-11-21

Abstract excerpt

While chromosomal architecture varies among cell types, little is known about how this organization is established or its role in development. We integrated Hi-C, RNA-seq and ATAC-seq during cardiac differentiation from human pluripotent stem cells to generate a comprehensive profile of chromosomal architecture. We identified active and repressive domains that are dynamic during cardiogenesis and recapitulate in...

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Literature Corpus work: 6e9c636c-a93a-59d3-9345-22941126cf54
DOI: 10.1101/222877

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