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Article

Chromosomal silencing and localization are mediated by different domains of Xist RNA.

Nature genetics - 1 Feb 2002

Wutz Anton, Rasmussen Theodore P, Jaenisch Rudolf

Abstract excerpt

The gene Xist initiates the chromosomal silencing process of X inactivation in mammals. Its product, a noncoding RNA, is expressed from and specifically associates with the inactive X chromosome in female cells. Here we use an inducible Xist expression system in mouse embryonic stem cells that recapitulates long-range chromosomal silencing to elucidate which Xist RNA sequences are necessary for chromosomal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11780141
DOI: 10.1038/ng820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Chromosomal silencing and localization are mediated by different domains of Xist RNA.PMID 11780141Read ↗

Advances in understanding chromosome silencing by the long non-coding RNA Xist.Semantic proximity Read ↗

Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expressionSemantic proximity Read ↗

Unleashing XIST from X-chromosome inactivationSemantic proximity Read ↗

Multiple distinct domains of human XIST are required to coordinate gene silencing and subsequent heterochromatin formationSemantic proximity Read ↗

Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation.Semantic proximity Read ↗

Structural organization of the inactive X chromosome in the mouse.Semantic proximity Read ↗

Xist-dependent imprinted X inactivation and the early developmental consequences of its failure.Semantic proximity Read ↗

X-chromosome inactivation: the molecular basis of silencing.Semantic proximity Read ↗

Independent recruitment of PRC1 and PRC2 by human XISTSemantic proximity Read ↗

Human XIST RNA acts early to condense architecture which facilitates A-repeat density-dependent initiation of gene silencingSemantic proximity Read ↗

Evolutionary conservation of possible functional domains of the human and murine XIST genes.Semantic proximity Read ↗

Tsix-mediated repression of Xist accumulation is not sufficient for normal random X inactivation.Semantic proximity Read ↗

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