Article

Integrated analysis of Xist upregulation and gene silencing at the onset of random X-chromosome inactivation at high temporal and allelic resolution

2020-07-21

Abstract excerpt

To ensure dosage compensation between the sexes, one randomly chosen X chromosome is silenced in each female cell in the process of X-chromosome inactivation (XCI). XCI is initiated during early development through upregulation of the long non-coding RNA Xist, which mediates chromosome-wide gene silencing. Cell differentiation, Xist upregulation and silencing are thought to be coupled at multiple levels to ensure...

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Literature Corpus work: 1c8fda7a-2e7e-50f8-bc92-dd4bcbd646ef
DOI: 10.1101/2020.07.20.211573

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