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Article

Histone variant macroH2A confers resistance to nuclear reprogramming.

The EMBO journal - 6 May 2011

Pasque Vincent, Gillich Astrid, Garrett Nigel, Gurdon John B

Abstract excerpt

How various layers of epigenetic repression restrict somatic cell nuclear reprogramming is poorly understood. The transfer of mammalian somatic cell nuclei into Xenopus oocytes induces transcriptional reprogramming of previously repressed genes. Here, we address the mechanisms that restrict reprogramming following nuclear transfer by assessing the stability of the inactive X chromosome (Xi) in different stages of...

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Share to Cellular Reprogramming
Share to Chromosomal Instability
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pluripotent Stem Cells

Share to RNA, Long Noncoding

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Identifiers

PMID: 21552206
DOI: 10.1038/emboj.2011.144
PMCID: PMC3116279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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