Article

Independent recruitment of PRC1 and PRC2 by human XIST

2020-09-21

Abstract excerpt

XIST establishes inactivation across its chromosome of origin, even when expressed from autosomal transgenes. To identify the regions of human XIST essential for recruiting heterochromatic marks we generated a series of overlapping deletions in an autosomal inducible XIST transgene. We examined the ability of each construct to enrich its unified XIST territory with the histone marks established by PRC1 and PRC2 as...

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Literature Corpus work: b9a5567f-889c-5f7b-a3c6-273999093ae2
DOI: 10.1101/2020.09.21.305904

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