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Article

Structural organization of the inactive X chromosome in the mouse.

Nature - 28 Jul 2016

Giorgetti Luca, Lajoie Bryan R, Carter Ava C, Attia Mikael, Zhan Ye, Xu Jin, Chen Chong Jian, Kaplan Noam, Chang Howard Y, Heard Edith, Dekker Job

Abstract excerpt

X-chromosome inactivation (XCI) involves major reorganization of the X chromosome as it becomes silent and heterochromatic. During female mammalian development, XCI is triggered by upregulation of the non-coding Xist RNA from one of the two X chromosomes. Xist coats the chromosome in cis and induces silencing of almost all genes via its A-repeat region, although some genes (constitutive escapees) avoid silencing...

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Source

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Identifiers

PMID: 27437574
DOI: 10.1038/nature18589
PMCID: PMC5443622

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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