Article

Cell type-specific genetic regulation of expression in the granule cell layer of the human dentate gyrus

2019-04-17

Abstract excerpt

Laser capture microdissection followed by RNA-seq (LCM-seq) was used to profile the transcriptional landscape of the granule cell layer of the dentate gyrus (DG-GCL) in human hippocampus, and contrasted to homogenate tissue. We identified widespread cell type-specific aging and genetic effects in the DG-GCL that were either missing or directionally discordant in corresponding bulk hippocampus RNA-seq data from lar...

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Literature Corpus work: f9f4bd32-07e3-55d3-9ccd-05131f8dac40
DOI: 10.1101/612200

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