Article

Single-cell dissection of schizophrenia reveals neurodevelopmental-synaptic axis and transcriptional resilience

2020-11-09

Abstract excerpt

Schizophrenia is a devastating mental disorder with a high societal burden, complex pathophysiology, and diverse genetic and environmental risk factors. Its complexity, polygenicity, and small-effect-size and cell-type-specific contributors have hindered mechanistic elucidation and the search for new therapeutics. Here, we present the first single-cell dissection of schizophrenia, across 500,000+ cells from 48 pos...

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Literature Corpus work: a1760c7d-7fd6-5267-b983-f5d2771faf9b
DOI: 10.1101/2020.11.06.20225342

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