Article

Single-cell anatomical analysis of human hippocampus and entorhinal cortex uncovers early-stage molecular pathology in Alzheimer’s disease

2021-07-01

Abstract excerpt

The human hippocampal formation plays a central role in Alzheimer’s disease (AD) progression, cognitive traits, and the onset of dementia; yet its molecular states in AD remain uncharacterized. Here, we report a comprehensive single-cell transcriptomic dissection of the human hippocampus and entorhinal cortex across 489,558 cells from 65 individuals with varying stages of AD pathology. We transcriptionally charact...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 70dd3cbb-36ad-57e0-b0dc-66b35c49a2b5
DOI: 10.1101/2021.07.01.450715

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell anatomical analysis of human hippocampus and entorhinal cortex uncovers early-stage molecular pathology in Alzheimer’s diseaseDOI 10.1101/2021.07.01.450715Read

Molecular Diversity Among Adult Human Hippocampal and Entorhinal CellsSemantic proximity Read

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation.Semantic proximity Read

Single-nucleus transcriptomics identifies a shared vulnerable excitatory neuronal population across typical and atypical Alzheimer’s diseaseSemantic proximity Read

Integrative Transcriptomic Analyses of Hippocampal–Entorhinal System Subfields Identify Key Regulators in Alzheimer's DiseaseSemantic proximity Read

Single-cell transcriptomic analysis elucidates APOE genotype specific changes across cell types in two brain regions in Alzheimer’s diseaseSemantic proximity Read

Transcriptional Patterns in Stages of Alzheimer's Disease Are Cell-Type–Specific and Partially Converge with the Effects of Alcohol Use Disorder in HumansSemantic proximity Read

Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals novel associations with AD pathologySemantic proximity Read

A roadmap to human hippocampal neurogenesis in adulthood, aging and AD.Semantic proximity Read

A single cell brain atlas in human Alzheimer’s diseaseSemantic proximity Read

Molecular and cellular pathology of monogenic Alzheimer’s disease at single cell resolutionSemantic proximity Read

Multiregional single-cell profiling reveals shared and specialized cellular vulnerability in Alzheimer’s diseaseSemantic proximity Read

Single-cell atlas of transcriptomic vulnerability across multiple neurodegenerative and neuropsychiatric diseasesSemantic proximity Read