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Article

Cell-type deconvolution of bulk-blood RNA-seq reveals biological insights into neuropsychiatric disorders.

American journal of human genetics - 1 Feb 2024

Boltz Toni, Schwarz Tommer, Bot Merel, Hou Kangcheng, Caggiano Christa, Lapinska Sandra, Duan Chenda, Boks Marco P, Kahn Rene S, Zaitlen Noah, Pasaniuc Bogdan, Ophoff Roel

Abstract excerpt

Genome-wide association studies (GWASs) have uncovered susceptibility loci associated with psychiatric disorders such as bipolar disorder (BP) and schizophrenia (SCZ). However, most of these loci are in non-coding regions of the genome, and the causal mechanisms of the link between genetic variation and disease risk is unknown. Expression quantitative trait locus (eQTL) analysis of bulk tissue is a common...

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Identifiers

PMID: 38306997
DOI: 10.1016/j.ajhg.2023.12.018
PMCID: PMC10870131

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