Article

Neuronal and glial 3D chromatin architecture illustrates cellular etiology of brain disorders

2020-05-16

Abstract excerpt

Cellular heterogeneity in the human brain obscures the identification of robust cellular regulatory networks. Here we integrated genome-wide chromosome conformation in purified neurons and glia with transcriptomic and enhancer profiles to build the gene regulatory landscape of two major cell classes in the human brain. Within glutamatergic and GABAergic neurons, we were able to link enhancers to their cognate gene...

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Literature Corpus work: 1c345e38-39ae-502c-8a89-0347c4976d41
DOI: 10.1101/2020.05.14.096917

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