Article

Single-cell deconvolution of 3,000 post-mortem brain samples for eQTL and GWAS dissection in mental disorders

2021-01-21

Abstract excerpt

Thousands of genetic variants acting in multiple cell types underlie complex disorders, yet most gene expression studies profile only bulk tissues, making it hard to resolve where genetic and non-genetic contributors act. This is particularly important for psychiatric and neurodegenerative disorders that impact multiple brain cell types with highly-distinct gene expression patterns and proportions. To address this...

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Literature Corpus work: 768618e5-8763-51e0-b595-859bd1604f5a
DOI: 10.1101/2021.01.21.426000

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