Article
Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk.
Nature neuroscience - 1 Apr 2020
Jaffe Andrew E, Hoeppner Daniel J, Saito Takeshi, Blanpain Lou, Ukaigwe Joy, Burke Emily E, Collado-Torres Leonardo, Tao Ran, Tajinda Katsunori, Maynard Kristen R, Tran Matthew N, Martinowich Keri, Deep-Soboslay Amy, Shin Joo Heon, Kleinman Joel E, Weinberger Daniel R, Matsumoto Mitsuyuki, Hyde Thomas M
Abstract excerpt
Specific cell populations may have unique contributions to schizophrenia but may be missed in studies of homogenate tissue. Here laser capture microdissection followed by RNA sequencing (LCM-seq) was used to transcriptomically profile the granule cell layer of the dentate gyrus (DG-GCL) in human hippocampus and contrast these data to those obtained from bulk hippocampal homogenate. We identified widespread...
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