Article

Cell group analysis reveals changes in upper-layer neurons associated with schizophrenia

2020-10-23

Abstract excerpt

Genome-wide association studies (GWAS) of schizophrenia (SCZ) have revealed over 100 risk loci. We investigated whether these SCZ-associated variants regulate gene expression by cell type. Using a fully unsupervised deconvolution method, we calculated gene expression by clusters of estimated cell types (cell-groups, CGs). Five CGs emerged in the dorsolateral prefrontal cortices (DLPFC) of 341 donors with and witho...

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Literature Corpus work: 6697209a-9b66-50f4-9a9c-8b618bb2f33b
DOI: 10.1101/2020.10.22.351213

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