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Article

Single-cell multi-cohort dissection of the schizophrenia transcriptome.

Science (New York, N.Y.) - 24 May 2024

Ruzicka W Brad, Mohammadi Shahin, Fullard John F, Davila-Velderrain Jose, Subburaju Sivan, Tso Daniel Reed, Hourihan Makayla, Jiang Shan, Lee Hao-Chih, Bendl Jaroslav, Voloudakis Georgios, Haroutunian Vahram, Hoffman Gabriel E, Roussos Panos, Kellis Manolis

Abstract excerpt

The complexity and heterogeneity of schizophrenia have hindered mechanistic elucidation and the development of more effective therapies. Here, we performed single-cell dissection of schizophrenia-associated transcriptomic changes in the human prefrontal cortex across 140 individuals in two independent cohorts. Excitatory neurons were the most affected cell group, with transcriptional changes converging on...

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Identifiers

PMID: 38781388
DOI: 10.1126/science.adg5136
PMCID: PMC12772489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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