Article

Combinatorial CRISPR screening reveals functional buffering in autophagy

2020-07-28

Abstract excerpt

<h4>ABSTRACT</h4> Functional genomics studies in model organisms and human cell lines provided important insights into gene functions and their context-dependent role in genetic circuits. However, our functional understanding of many of these genes and how they combinatorically regulate key biological processes, remains limited. To enable the SpCas9-dependent mapping of gene-gene interactions in human cells, we e...

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Literature Corpus work: f9d1d559-41e4-57fc-88b5-d317e2759215
DOI: 10.1101/2020.07.28.201152

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