Article

Efficient gene knockout and genetic interactions: the IN4MER CRISPR/Cas12a multiplex knockout platform

2023-01-03

Abstract excerpt

Genetic interactions mediate the emergence of phenotype from genotype, but initial technologies for combinatorial genetic perturbation in mammalian cells suffer from inefficiency and are challenging to scale. Recent focus on paralog synthetic lethality in cancer cells offers an opportunity to evaluate different approaches and improve on the state of the art. Here we report a meta-analysis of CRISPR genetic interac...

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Literature Corpus work: 8f5dedb7-99a3-5a0e-9e82-6bb05da395ec
DOI: 10.1101/2023.01.03.522655

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