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A platform for the systematic interrogation of genetic interactions in human cells: 26 gene by genome-wide double knockout screens as a proof of concept

2025-08-06

Abstract excerpt

Genetic interactions are typically studied by looking at the phenotype that results from disruption of pairs of genes, as well as from higher order combinations of perturbations. Systematically interrogating all pairwise combinations provides insights into how genes are organized into pathways and complexes to sustain cellular homeostasis and how interacting genes respond to stressors and external signals. Genetic...

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Literature Corpus work
5cb180c7-8ecb-5ee7-b024-36900230cd8e
DOI
10.1101/2025.08.04.665369
Open publication

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A platform for the systematic interrogation of genetic interactions in human cells: 26 gene by genome-wide double knockout screens as a proof of conceptDOI 10.1101/2025.08.04.665369
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