Article

BAGEL: A computational framework for identifying essential genes from pooled library screens

2015-11-27

Abstract excerpt

<h4>Background</h4> The adaptation of the CRISPR-Cas9 system to pooled library gene knockout screens in mammalian cells represents a major technological leap over RNA interference, the prior state of the art. New methods for analyzing the data and evaluating results are needed. <h4>Results</h4> We offer BAGEL (Bayesian Analysis of Gene EssentiaLity), a supervised learning method for analyzing gene knockout scree...

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Literature Corpus work: 51d88985-7599-572d-9546-85272d61d9c3
DOI: 10.1101/033068

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