Article

Functional modules predict cancer-relevant genetic interactions in mammalian cells

2025-12-21

Abstract excerpt

Genetic interactions can reveal gene function and identify cancer-relevant synthetic lethals, but systematic mapping in human cells is constrained by inefficient reagents, vast combinatorial search space, and diversity of cell types. Here, we leverage principles from yeast genetic networks to identify human gene modules enriched for genetic interactions. Using our Cas12a-based In4mer combinatorial knockout platfor...

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Literature Corpus work: 563922d7-9eaf-520d-84e8-8ebeae8c5117
DOI: 10.64898/2025.12.18.695201

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