Article
Towards an Integrated Map of Genetic Interactions in Cancer Cells
2017-03-27
Abstract excerpt
<h4>ABSTRACT</h4> Cancer genomes often harbor hundreds of molecular aberrations. Such genetic variants can be drivers or passengers of tumorigenesis and, as a side effect, create new vulnerabilities for potential therapeutic exploitation. To systematically identify genotype-dependent vulnerabilities and synthetic lethal interactions, forward genetic screens in different genetic backgrounds have been conducted. We...
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Identifiers and source
- Literature Corpus work
- 4820f76b-11b2-5066-999f-5862303f7d59
- DOI
- 10.1101/120964