Article

Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screens

2025-06-30

Abstract excerpt

Genetic interaction (GI) networks in model organisms have revealed how combinations of genome variants can impact phenotypes. To advance efforts toward a reference human GI network, we developed the q uantitative G enetic Interaction (qGI) score, a method for precise GI measurement from genome-wide CRISPR-Cas9 screens in different query mutants constructed in a single human cell line. We found surprising prevale...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 70a959a5-1173-52c6-8906-c2457bc47ba2
DOI: 10.1101/2025.06.30.662330

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screensDOI 10.1101/2025.06.30.662330Read

Hierarchical organization of the human cell from a cancer coessentiality networkSemantic proximity Read

Integrated cross-study datasets of genetic dependencies in cancerSemantic proximity Read

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.Semantic proximity Read

Perturbational fitness analysis of CRISPR screens uncovers information-theoretic relation between gene function and selectionSemantic proximity Read

Toward an integrated map of genetic interactions in cancer cells.Semantic proximity Read

Towards an Integrated Map of Genetic Interactions in Cancer CellsSemantic proximity Read

A genome-scale single cell CRISPRi map of <i>trans</i> gene regulation across human pluripotent stem cell linesSemantic proximity Read

scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens.Semantic proximity Read

Measuring error rates in genomic perturbation screens: gold standards for human functional genomicsSemantic proximity Read

Prime Editing Driven Functional Genomics: Bridging Genotype to Phenotype in the Post-Genomic Era.Semantic proximity Read

High-resolution mapping of cancer cell networks using co-functional interactionsSemantic proximity Read

The phenotypic landscape of essential human genesSemantic proximity Read