Age-related erosion of X chromosome inactivation in human tissues

Abstract excerpt

Age-related diseases often show sex differences, yet their molecular bases remain unclear. Animal models suggest that age-related disruption of X-chromosome inactivation (XCI) occurs in female mice. We test whether this phenomenon extends to humans using bulk and single-cell datasets. We find that age-dependent escape from XCI also occurs in human females, particularly among genes at the distal ends of the X-chrom...

Topics

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• Chromosomes, Human, X
• Genes, X-Linked
• Genome, Human
• Organ Specificity
• Sequence Analysis, RNA
• Single-Cell Analysis
• Transcriptome
• X Chromosome Inactivation

Identifiers and source

Literature Corpus work

f855ae32-2502-512d-8374-41013b856c40

DOI

10.64898/2025.12.09.693282