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Article

Landscape of X chromosome inactivation across human tissues.

Nature - 11 Oct 2017

Tukiainen Taru, Villani Alexandra-Chloé, Yen Angela, Rivas Manuel A, Marshall Jamie L, Satija Rahul, Aguirre Matt, Gauthier Laura, Fleharty Mark, Kirby Andrew, Cummings Beryl B, Castel Stephane E, Karczewski Konrad J, Aguet François, Byrnes Andrea, Lappalainen Tuuli, Regev Aviv, Ardlie Kristin G, Hacohen Nir, MacArthur Daniel G

Abstract excerpt

X chromosome inactivation (XCI) silences transcription from one of the two X chromosomes in female mammalian cells to balance expression dosage between XX females and XY males. XCI is, however, incomplete in humans: up to one-third of X-chromosomal genes are expressed from both the active and inactive X chromosomes (Xa and Xi, respectively) in female cells, with the degree of 'escape' from inactivation varying...

Topics

Chromosomes, Human, X
Female
Genes, X-Linked
Genome, Human
Genomics
Humans
Male
Organ Specificity
Phenotype
Sequence Analysis, RNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Single-Cell Analysis

Transcriptome

X Chromosome Inactivation

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Open in PubMed Open full text

Identifiers

PMID: 29022598
DOI: 10.1038/nature24265
PMCID: PMC5685192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Landscape of X chromosome inactivation across human tissues.PMID 29022598Read ↗

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