Article

Cross-tissue analysis of allelic X-chromosome inactivation ratios resolves features of human development

2021-09-14

Abstract excerpt

X-chromosome inactivation (XCI) is a random, permanent, and developmentally early epigenetic event that occurs during mammalian embryogenesis. We harness these features of XCI to investigate characteristics of early lineage specification events during human development. We initially assess the consistency of X-inactivation and establish a robust set of XCI-escape genes. By analyzing variance in XCI ratios across t...

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Literature Corpus work: 2687bad1-1d7d-5ce7-b490-2b06091392c3
DOI: 10.1101/2021.09.13.460075

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