Article

Escape from X inactivation varies across genes and tissues and shapes sex-biased sex chromosome gene expression

2025-12-22

Abstract excerpt

Sex differences in human health and disease are shaped by complex interactions between hormones, environment, and genetic factors – including those associated with sex chromosomes. While X chromosome inactivation (XCI) in females generally silences one copy of the X to equalize dosage with males, a subset of genes “escape” XCI and remain expressed from both X chromosomes. In this study, I integrate allele-specific...

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Literature Corpus work: b7f99ccd-f4f5-57b7-8670-c00858f6f994
DOI: 10.64898/2025.12.19.695225

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