Article
Heritability of skewed X-inactivation in female twins is tissue-specific and dependent on age
2019-03-31
Abstract excerpt
To balance the X-linked transcriptional dosages between the sexes, one of the two X-chromosomes is randomly selected to be inactivated in somatic tissues of female placental mammals. Non-random, or skewed X-chromosome inactivation (XCI) toward one parental X has been observed in female somatic tissues, and this skewing effect has been associated with several complex human traits. However, the extent of the influen...
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Identifiers and source
- Literature Corpus work
- fa582b26-eb4b-543f-a2b5-797cbc200fe1
- DOI
- 10.1101/593251