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Article

Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age.

Nature communications - 25 Nov 2019

Zito Antonino, Davies Matthew N, Tsai Pei-Chien, Roberts Susanna, Andres-Ejarque Rosa, Nardone Stefano, Bell Jordana T, Wong Chloe C Y, Small Kerrin S

Abstract excerpt

Female somatic X-chromosome inactivation (XCI) balances the X-linked transcriptional dosages between the sexes. Skewed XCI toward one parental X has been observed in several complex human traits, but the extent to which genetics and environment influence skewed XCI is largely unexplored. To address this, we quantify XCI-skew in multiple tissues and immune cell types in a twin cohort. Within an individual,...

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Share to Aged, 80 and over
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, X

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Share to Genes, X-Linked

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Share to X Chromosome Inactivation

Source

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Identifiers

PMID: 31767861
DOI: 10.1038/s41467-019-13340-w
PMCID: PMC6877649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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