Article

X-inactivation states of single cell transcriptomes reveal cellular phylogenies in human females

2022-11-13

Abstract excerpt

Human females undergo X-inactivation (Xi), whereby one copy of X is randomly inactivated early in development, then propagated through cell division. Because Xi state is inherited, its measurement in populations of cells encodes information about the phylogeny that created them and their relationships to other cells. We present a method, inactiveXX, to determine the Xi state of single cell transcriptomes, and demo...

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Literature Corpus work: d5efa6de-84a1-5dea-aa74-aab206df7065
DOI: 10.1101/2022.11.10.515645

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