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Article

Age-associated skewing of X-inactivation ratios of blood cells in normal females: a candidate-gene analysis approach.

Experimental hematology - 1 Oct 2005

Chagnon Pierre, Provost Sylvie, Belisle Claude, Bolduc Véronique, Gingras Marianne, Busque Lambert

Abstract excerpt

X-inactivation is a random process that occurs in females early during embryogenesis. Females are mosaics with an equal proportion of cells with the paternal (Xp) or maternal X-chromosome (Xm) in the active state. However, close to 40% of healthy females aged more than 60 y.o. present a significant skewing of X-inactivation ratios (Xp:Xm >3 :1). The exact etiology of this age-associated skewing (AAS) in blood...

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Identifiers

PMID: 16219543
DOI: 10.1016/j.exphem.2005.06.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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